ERBB2 and breast cancer: The in vivo tumor growth inhibition studies against HER2-positive breast cancer was performed using phosphate buffer saline (PBS) as a control, free AHNP, non-loaded nanoconjugate, and AHNP-incorporated conjugates via intravenous administration in nude mice inoculated with BT474 breast cancer cells (HER2-positive), which developed to the tumor with a size of 120 mm3 [123].