Stilbene derivatives particularly resveratrol play a significant role in the activation of Nrf2-related gene transcription which induces expression of cytoprotective enzymes such as NQO1, glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (GCLC) and heme oxygenase-1 (HO-1) thus leading to protection against cancer [71]. This evidence concerns the gene GCLC and cancer.