We found that 34 FSHD-induced genes were expressed in both FSHD-Hi and FSHD-Lo populations, including reported DUX4 targets LEUTX, ZSCAN4, MBD3L2, TRIM43, KHDC1L and CCNA1 [4, 20, 25] indicating that they may perform as a core set of responsive and interactive genes during FSHD progression (Fig 2D). Here, DUX4 is linked to facioscapulohumeral muscular dystrophy.