F2RL1 and ovarian cancer: Tissue Factor (TF)-FVIIa is known to induce PAR2 activation in ovarian cancer [28], so relative expression of TF or trypsin-1/2 (encoded by PRSS1/2), which accounts for the majority of trypsin isoforms [29], was compared between ovarian surface epithelium (OSE) and ovarian cancer tissues.