Similar to our results, miR‐124 also suppressed OSCC cell migration and invasion by targeting ITGB1.32 miR‐223 inhibited cell invasion and migration in prostate cancer by downregulating ITGB1.33 Meanwhile, miR‐29c was found to inhibit the growth of pancreatic cancer cells by inhibiting ITGB1.34 In our study, miR‐374b inhibited cell viability, migration and invasion in NSCLC by downregulating ITGB1. This evidence concerns the gene ITGB1 and Familial prostate cancer.