Western blot analysis further indicated that inhibition of miR-183-5p led to a down-regulation in the expression of VEGFA, VEGFAR2, ANG2, PIGF, MMP-2 and MMP-9 along with up-regulated FOXO1 expression in tumor tissues (Figure 6D–6E, p < 0.05). This evidence concerns the gene MMP2 and neoplasm.