Our data suggest that systemic inflammation (in terms of IL-18, sIL-2Rα, and TNF-α) is not associated with the underlying SHD, but rather with the arrhythmia “per se.” This finding is furtherly confirmed by our logistic regression analysis showing no relationship between inflammatory markers such as selected cytokines serum levels and SHD. The gene discussed is IL18; the disease is cardiac arrhythmia.