ADPKD is typically characterized by the growth of renal cysts, although a significant proportion of patients develop hypertension prior to kidney dysfunction, suggesting PKD2 channels perform physiological functions in vascular wall cell types (Torres et al., 2007; Valero et al., 1999; Martinez-Vea et al., 2004). The gene discussed is PKD2; the disease is autosomal dominant polycystic kidney disease.