Based on this technique, several novel diagnostic or prognostic biomarkers have been developed for gastric cancer, including microRNA signatures,18 a panel of afamin, clusterin, vitamin D binding protein (VDBP) and haptoglobin,19 and exosomal TRIM3 21 for gastric cancer screen; apolipoprotein C‐III (apoC‐III) fragment,15 fibrinogen α‐chain, apoA‐II and apoC‐I20 for diagnosis; and apoC‐III fragment15 for prognosis prediction. The gene discussed is CLU; the disease is gastric cancer.