The P53, MSH2, Tm‐4, NLR, MLR, hs‐CRP, TNF‐α, IL‐6 levels, and the smoking, drinking, and occupational exposure to chemicals rates in the AFP‐Negative HCC patients were significantly higher than those in controls (P < .05, Figure 3A‐H). The gene discussed is TP53; the disease is hepatocellular carcinoma.