The regression model for AFP‐Negative HCC was: Logit (P) = 707.379 − 7.167(NLR) − 23.925(MLR) − 17.162(hs‐CRP) − 0.041(TNF‐α) − 3.641(IL‐6) − 3.506(P53) − 0.679(MSH2) + 0.363(Tm‐4) − 99.383(drinking) − 172.883(smoking) − 179.393(occupational exposure to chemicals), see Table S2. This evidence concerns the gene IL6 and hepatocellular carcinoma.