EP4 plays a role in the proliferation and angiogenesis of cervical cancer cells since GW627368X (a highly selective EP4 antagonist) inhibits the proliferation and angiogenesis of cervical carcinoma by blocking EP4/EGFR signaling pathway in cervical cancer cell lines (HeLa, SiHa and ME 180) and suppresses the tumor size in xenograft mice model [84]. Here, EGFR is linked to cervical carcinoma.