Sales et al. reported that the syntheses of COX-2, PGE2, EP2, EP4 and cyclic adenosine monophosphate (cAMP) are up-regulated in cervical cancer tissue compared to that in the healthy cervix, suggesting that PGE2 may regulate neoplastic cell function via the EP2/EP4 receptors [75]. This evidence concerns the gene PTGS2 and cervical cancer.