PGE2 stimulates vascular endothelial growth factor (VEGF) expression in Ishikawa cells (a human endometrial adenocarcinoma cell line) via EP2-cAMP-mediated transactivation of the epidermal growth factor receptor (EGFR) and extracellular signal-regulated kinases 1/2 (ERK1/2) pathways [43]. Here, EGFR is linked to endometrium adenocarcinoma.