Given that RNA-binding proteins such as hnRNP A1, FUS, and TDP43 have been associated with snRNP biology and splicing defects in ALS motor neuron diseases (Nussbacher et al., 2019), we asked whether they could be modulated by flunarizine at the protein level (Figure 5). Here, TARDBP is linked to amyotrophic lateral sclerosis.