They are also lost in cells of patients affected with amyotrophic lateral sclerosis (ALS), an adult-onset motor neuron disease (Yamazaki et al., 2012; Tsuiji et al., 2013; Cauchi, 2014; Sun et al., 2015; Yu et al., 2015) and in tissues of ALS mouse models carrying mutated forms of SOD1, FUS, or TDP-43 (Shan et al., 2010; Gertz et al., 2012; Kariya et al., 2012; Ishihara et al., 2013; Sun et al., 2015). The gene discussed is TARDBP; the disease is motor neuron disorder.