Hepatic deletion of genes in the PI3K–Akt–mTOR pathway, including Pten and Akt1 in Akt2, induces HCC (Horie et al., 2004; Watanabe et al., 2005; Kenerson et al., 2013; Wang et al., 2016). The gene discussed is AKT2; the disease is hepatocellular carcinoma.