IL1RL1 and cerebral malaria: Specifically, IL-33 has been shown to potentiate mast cell activity (Komai-Koma et al., 2012; Joulia et al., 2017), while mast cell degranulation has been separately shown to correlate with P. falciparum severity (Wilainam et al., 2015); though it also has been demonstrated to promote the expansion of ST2+ ILC2s in the skin (Salimi et al., 2013), a cell type whose systemic expansion is shown to correlate with improved protection against cerebral malaria (Besnard et al., 2015).