Considering the interaction between IL-6 and YKL-40, their potential as prognostic biomarkers and treatment targets in GBM, we explored the prespecified hypotheses that high plasma IL-6 and YKL-40 pre-treatment or at relapse correlate with malignancy grade (WHO grade) of gliomas and have an adverse impact on survival in patients with glioma WHO grade IV. Here, CHI3L1 is linked to central nervous system cancer.