Exploring the TCGA dataset [http://gliovis.bioinfo.cnio.es/ (37)] IL6 and CHI3L1 RNA expression in glioma WHO grade II-IV tumor tissue were both separately able to differentiate IDH wildtype from IDH mutated gliomas (p < 0.001; pair-wise t-tests with Bonferroni correction), with highest expression in IDH wildtype, which should mainly represent GBMs (Supplementary File 4). This evidence concerns the gene IL6 and glioma.