CRLS1 and central nervous system cancer: In addition, comparing the five genes against the distribution of all genes, PGS1 and CRLS1 have significantly smaller CERES gene dependency scores (Student’s t-test, pPGS1 < 2.2 10–16 and pCRLS1 = 0.01455), which indicates that these two genes are particularly essential for glioma cell lines and together with our model based predictions, suggests they could be promising novel drug targets.