The relevance of the role of these non-human genes in immune responses could be confirmed by literature: lanA1 (viral protein LanA1; role in host-virus interaction) (39), cscK (bacterial fructokinase; role in TLR4 activation) (40), dop (bacterial pup deamidase; role in resistance to infection) (41), rpoD (bacterial sigma factor for RNA polymerase; role in exponential growth bacteria) (42), lectin (role in activation of innate immune system) (43), lacZ (bacterial beta-galactosidase; Th1-associated) (44), env (viral envelope glycoprotein gp160; role in immune evasion) (45). Here, OPRD1 is linked to infection.