IGF1 and Alzheimer disease: In addition, miR-206 can enhance LPS-induced inflammation and promote the release of Aβ in microglia by binding to the 3'-UTR of insulin-like growth factor 1 (IGF-1) so that IGF-1 exposure can mitigate miR-206-induced inflammation in microglia, indicating that the miR-206/IGF-1 signaling pathway may be associated with microglial inflammation in AD (63).