For example, miR-9, miR-29, miR-29a/b-1, miR-124, miR-101, miR-107, miR-298, and miR-328 contribute to the increase of Aβ production, all of them can exhibit the reduced expression in patients or model animals with AD by regulating the expression of BACE1 and/or APP (15–18). The gene discussed is APP; the disease is Alzheimer disease.