Similarly, autophagy-related genes including LC3-II/LC3-I, Beclin1, Atg7, and autophagic influx are markedly decreased in D-galactose-induced AD rat models when compared with the control; however, 8-week swimming training (autophagy mimics) alleviates cognitive function defects via restoring autophagy in an AD rat model (78). Here, ATG7 is linked to Alzheimer disease.