As illustrated from one of previous studies, increasing induction of autophagy prior to the development of AD-like pathology in 3×Tg-AD mice can reduce the levels of soluble Aβ, Tau and amyloid plaques, whereas the induction after the formation of mature plaques and tangles has no effect on AD-like pathology or cognitive deficits (97). This evidence concerns the gene MAPT and Alzheimer disease.