This is linked with the recent discovery that RA T cells lack N-myristoyltransferase (NMT)-induced AMP-activated protein kinase (AMPK) activation which is a positive regulator of autophagy by suppressing the mammalian target of rapamycin (mTOR) activity (Kim et al., 2013; Cassano et al., 2014; Wen et al., 2019). This evidence concerns the gene MTOR and rheumatoid arthritis.