All these pathways are involved in cell signal transmission and could have crosstalk with PI3K/AKT/mTOR signaling pathway, which is used to achieve the proliferation, differentiation, and apoptosis of immune cells in RA (Shu et al., 2017; Feng and Qiu, 2018; Wang et al., 2019a). This evidence concerns the gene AKT1 and rheumatoid arthritis.