In this regard, we observed a dramatic increase in the expression of p-AMPK in the early phase of CCl4-induced ALI (i.e., at 24 h) upon bicyclol treatment, which was accompanied with a significant decrease in the expression of p-mTOR, p-JNK, p-ERK, as well as p-p38. The gene discussed is MAPK8; the disease is acute respiratory distress syndrome.