Current evidence-based treatments for HF mainly include neurohormonal inhibitors, such as medications targeting the renin-angiotensin aldosterone system and the β-adrenergic receptor signaling pathway, mineral corticosteroid receptor antagonists, medications that improve the HF syndrome, such as inositol and diuretics, and mechanical devices (Ponikowski et al., 2016). The gene discussed is REN; the disease is hydrops fetalis.