Previous studies have shown that SM combined with concurrent HF medication is better than concurrent HF medication alone for the improvement of 6-min walk test results, ejection fraction, BNP level, etc. Our previous study showed that SM and TMZ improve energy metabolism in primary cardiomyocytes after ischemia-reperfusion (Wang et al., 2019a), highlighting the beneficial effects of SM on energy metabolism in HF. Here, NPPB is linked to hydrops fetalis.