APOE and achalasia-alacrima syndrome: Infusion of AngII via subcutaneous osmotic minipumps in ApoE–/– mice has also been shown to result in the formation of AAAs, which could mimic the inflammatory microenvironment and exhibit many characteristics of human AAA including rupture of the elastic layer, activation of matrix metalloproteinases, macrophage infiltration and so on (Senemaud et al., 2017).