In lymphoblastoid cell lines (LCLs) from AD patients, RV increased the expression of genes encoding known antioxidants defenses (CAT, copper chaperone for SOD 1, GST zeta 1) and anti-aging factor sirtuin-1 (SIRT-1; Cosín-Tomàs et al., 2019). This evidence concerns the gene SIRT1 and Alzheimer disease.