Upregulation of peroxisome proliferator-activated receptor (PPAR) alpha expression could be associated with modulation of markers of cellular stress, inflammation, and AD pathology, such as the expression manganese superoxide dismutase (MnSOD), transcription of NF-κB and JNK phosphorylation, all significantly improved by pterostilbene. This evidence concerns the gene SOD2 and Alzheimer disease.