SORL1 and Alzheimer disease: SORL1 variants were first associated with LOAD in 2007 (Rogaeva et al., 2007), but a decrease in Sorla expression in the brain of AD patients had been already observed in 2004 by the Lah lab (Scherzer et al., 2004) and in 2005 by the Willnow lab (Andersen et al., 2005).