For instance, KLHL9- and ADSSL1-associated distal myopathies are reported to have a rather early onset between 10 and 20 years of age, while first symptoms in MYOT-associated distal myopathy are occurring between 50 and 60 years of age [7, 21, 22, 41, 42]. This evidence concerns the gene KLHL9 and distal myopathy.