A traditional paradigm suggests that individuals with HBV/HIV coinfection might have a worse prognosis from chronic liver disease than those with HBV monoinfection, typically linked with higher rates of HBeAg-positivity and higher viral loads,1,3 lower CD4+ T cell counts, increased incidence of liver fibrosis4 and hepatocellular carcinoma (HCC), higher rates of vertical HBV transmission, and higher overall mortality in those with HIV coinfection.5 The gene discussed is CD4; the disease is hepatocellular carcinoma.