Examples of higher OC risk estimates (OR = ~ 11, and OR = ~ 19) for BRIP1 mutations were reported [18, 27], but this discrepancy may be due to the varied participation of OC patients with a family history of OC and/or BC and BRCA1/2 mutation carrier exclusion in several studies, as well as modest sample sizes. This evidence concerns the gene BRIP1 and breast cancer.