BRIP1 and cancer: For comparison, no BRIP1, 2 RAD51C, and 2 RAD51D large mutations per ~ 11,000 subjects are reported in the gnomAD database, and 2 BRIP1, 5 RAD51C, and 3 RAD51D large mutations per ~ 10,000 cancer-free women older than age 70 are documented in the FLOSSIES database [92].