Significantly higher uptake of [11C]MC1 (COX-2) and [11C]ER176 (TSPO) was observed in the hand, elbow, and/or shoulder joints of two individuals with rheumatoid arthritis compared to other joints in the same individuals as well as in the corresponding joints of two healthy controls (Fig. 9). This evidence concerns the gene PTGS2 and rheumatoid arthritis.