The present study was aimed at investigating the effects of CRP at the different concentrations and times on the expression of vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), intercellular adhesion molecule-2 (ICAM-2), and vascular cell adhesion molecule-1 (VCAM-1), known as atherosclerosis-related genes in human coronary artery endothelial cells (HCAECs). The gene discussed is ICAM2; the disease is atherosclerosis.