Increased levels of Hsp70 and autoantibodies to Hsp70 in sera of RA or juvenile idiopathic arthritis (JIA) patients are found to be associated with the disease progression and activity (Zlacka et al. 2006; Najafizadeh et al. 2015), and numerous in vitro studies indicated pro-inflammatory properties for Hsp70 in their interactions with the innate immune cells. The gene discussed is HSPA1A; the disease is rheumatoid arthritis.