This study has revealed that senescence markers (i.e., SA-β-gal, p53, and p16) and SASP factors that antagonize differentiation (i.e., PAI-1 and TGFβ-1) are upregulated in SAT biopsies from patients with hypertrophic obesity and T2D and are positively correlated with subcutaneous adipocyte cell size [83]. The gene discussed is TP53; the disease is type 2 diabetes mellitus.