NLRP3 and type 2 diabetes mellitus: On the basis of the pathogenic effect of the NLRP3 inflammasome on CVD and the therapeutic role of BHB on its inhibition, the present study demonstrates that the SGLT2 inhibitor blocks NLRP3 inflammasome activation by raising circulating levels of BHB in patients with T2D at high CV risk, which could explain their cardioprotective effects.