STAT3 and colorectal carcinoma: Here, we illustrated that knockdown of BECN1 decreased the autophagic flux in CRC and that inhibition of autophagy attenuated the levels of STAT3 phosphorylation, suggesting that BECN1 regulates STAT3 phosphorylation independently of autophagy in CRC and that the role of BECN1 in CRC metastasis might depend on autophagy.