More research is necessary to better understand the role of necroptosis across different neurodegenerative diseases: whilst pharmacological inhibition of MLKL and other proteins in the necroptotic cascade is a therapeutic strategy under development for the treatment of neurodegenerative and other diseases2,18,59–61, our study raises cautions regarding potential adverse consequences of long-term inhibition of MLKL. Here, MLKL is linked to neurodegenerative disease.