PBRM1 and renal cell carcinoma: Suppression of immunostimulatory gene expression with loss of PBRM1 was confirmed by analysis of nearly 700 human RCC tumors across three independent cohorts, which corresponded with decreased immune infiltrates as analyzed by either gene expression profiling or immunohistochemistry, including two additional patient cohorts (Fig. 4g, Supplementary Fig. 3B).