For instance, genetically determined expression of FES was strongly associated with coronary artery disease (per 1 SD OR: 0.90, 95% CI: 0.88–0.92, Pcausal = 1.09 × 10−15), which is consistent with the genetic signal in GWAS by the tag SNP rs17514846 (PGWAS = 9.85 × 10−27) at the FURIN/FES locus. Here, FES is linked to coronary artery disorder.