In line with our considerations, application of GDC-0623 with anti-CD40 Ab in the MC-38 and B16-OVA models showed striking synergy between these drugs, resulting in significant suppression of B16-OVA tumor growth and tumor stasis in the MC-38 model (Fig. 3a/b; Supplementary Fig. 6A). Here, CD40 is linked to neoplasm.