First, it increases blood supply by sympatholytic effect in its sphere of innervation.[6,7] Second, SGB inhibits neuronal connections between the stellate ganglion and the brain, which may produce therapeutic effects in various diseases, such as post-herpetic neuralgia, post-traumatic stress disorder, hot flashes and sleep disturbances in breast cancer survivors.[8,16,17] In addition, SGB is reported to be effective for treatment of tension headache and headache following post-traumatic stress disorder.[18,19] The exact mechanism of analgesic action of SGB in these disorders remains unclear. The gene discussed is GPC3; the disease is Tension-type headache.