A Japanese team found that the CPT1B gene (carnitine palmitoyltransferase 1B) and the CHKB gene (choline kinase B), both involved in REM (rapid eye movement) regulation, are associated with narcolepsy type I.[12] Subsequent genome-wide association analysis revealed that narcolepsy is highly associated with the TCR alpha (T cell receptor alpha chain) loci,[13] which has been repeated in subsequent studies.[14] The TCR alpha locus produces a unique protein in T lymphocytes and plays an important role in identifying antigens bound to HLA. The gene discussed is CPT1B; the disease is narcolepsy.