Chi-square test was performed to calculate the P value, and it was illuminated that the expression of miR-363 had a negative association with tumor size (P < 0.05), TNM stage (P < 0.05), lymph node metastasis (P < 0.05), and the expression of NOB1 in osteosarcoma tissues (P < 0.05) (Table 1). The gene discussed is NOB1; the disease is osteosarcoma.