Xenograft tumors derived from TRAF4-knockout HT29 cells were treated with 5-Fu and exhibited a significant decrease in tumor growth, tumor mass, and tumor cell proliferation when compared to tumors derived from TRAF4-knockout cells that did not receive the 5-Fu treatment or to tumors retaining WT TRAF4 and treated with 5-Fu (Fig. 5j–m). The gene discussed is TRAF4; the disease is neoplasm.