In this context, we recently reported that the preconditioning of AD-MSCs with the hypoxic mimetic agent deferoxamine increased the level of the hypoxia-inducible factor HIF1α, which activates several intracellular pathways that finally result in a significant increase in the secretion of several potent angiogenic, neuroprotective, anti-inflammatory, and antioxidant factors [30], which could enable the concerted effect necessary for neurovascular recovery in DPN. The gene discussed is HIF1A; the disease is Alzheimer disease.