We showed previously that phosphorylation of GR on Serine 134 is elevated in TNBC relative to other breast cancer subtypes [16]; this p38 MAPK-dependent event was insensitive to GR ligands, but induced in response to cellular stress, including ROS/H2O2, hypoxia, and nutrient starvation [17], as well as loss of attachment (i.e., cell suspension) and stress-inducing chemotherapies [16] such as paclitaxel (Taxol), a taxane microtubule stabilizing drug routinely used as adjuvant or neoadjuvant chemotherapy in TNBC patients [16, 18]. Here, NR3C1 is linked to breast carcinoma.