Previously, we reported that cellular stress (i.e., H2O2, hypoxia, nutrient starvation) and stressful growth conditions such as growth in low attachment/suspension and chemotherapeutic agents (i.e., Taxol) increase phosphorylation of GR on Ser134, leading to the increased ligand-induced expression of selected GR target genes (e.g., BRK, HIF2, AhR) that are essential for advanced cancer phenotypes in TNBC [16, 17]. The gene discussed is PTK6; the disease is cancer.