We found that Prdx1 could regulate the expression of NEDD9, Aurora A, and HDAC6 in ESCC, but the relationship between these expression effects in ESCC and whether the action of Prdx1 to promote cilium disassembly and tumor invasion were achieved through regulation of the NEDD9-Aurora A-HDAC6 signal axis were inconclusive. Here, PRDX1 is linked to esophageal squamous cell carcinoma.