The anterior segment dysgenesis and craniofacial abnormalities (telecanthus, maxillary hypoplasia, microdontia, and oligodontia) in ARS are commonly a result of genetic disruption of neural crest cell migration and differentiation due to autosomal dominant mutations within the PITX2 or FOXC1 genes [4, 10–15]. The gene discussed is PITX2; the disease is Axenfeld-Rieger syndrome.