WNK2 and Noonan syndrome and Noonan-related syndrome: NFNS is a clinically independent autosomal dominant hereditary disease [6] and it is considered as a RASopathy, which are defined as a group of medical genetic syndromes caused by germline mutations in genes that encode components or regulators of the Ras/mitogen-activated protein kinase (MAPK) signaling pathway, including Noonan syndrome and Noonan-related syndromes [7].