Anti-RNP antibody reacts with proteins that are associated with U1 RNA and form U1snRNP, autoimmunity to RNP autoantigens is frequently seen in systemic autoimmune diseases including lupus and it may induce the occurrence of renal disease [23–25], thyroid hormone synthesis may be affected by impaired kidney function as mentioned earlier. Here, RNPC3 is linked to systemic lupus erythematosus.