Huang et al. [26] related that MMP-9 represents a potential biomarker which is overexpressed in several types of tumors (colarectal carcinoma, breast, pancreatic, ovaria, cervical, osteosarcoma non-small cell lung cancer (NSCLC), and giant cell tumor of bone (GCTB)), which makes MMP-9 a preferential candidate for the early detection of these diseases [26]. This evidence concerns the gene MMP9 and osteosarcoma.