In multivariate analysis, active alcoholism (OR = 2.17, 95% CI = 1.00–4.77, p = 0.05), MELD score (OR = 1.11, 95% CI = 1.01–1.22, p = 0.02), hemoglobin concentration (OR = 0.62, 95% CI = 0.51–0.78, p = 0.001), and serum IL-6 concentration (OR = 1.02, 95% CI = 1.01–1.04, p = 0.03), all at baseline, were independently associated with the risk of hospitalization due to hepatic decompensation during follow-up. This evidence concerns the gene IL6 and alcohol dependence.